By in Health & Fitness

Biogen Speeds New Alzheimer's Drug to Phase 3 Clinical Trial

Encouraging results from the Biogen Phase 1b Alzheimer's clinical trial for the new drug Aducanumab or BIIB037 were presented today at the 12th International Conference on Alzheimer’s and Parkinson’s Diseases and Related Neurological Disorders in Nice, France.

Biogen idec is manufacturing aducanumab; however aducanumab was originally developed by the Swiss biotech Neurimmune. The results of the clinical trial has sparked much interest in the scientific community as researchers continue the battle to find an effective treatment for Alzheimer's disease.

Biogen Phase 1b Clinical Trial

The participants of the trial were grouped into five groups. Four groups received a placebo and the fifth group was administered the drug. The drug is time and dose dependent. Only participants who were diagnosed with early or mild Alzheimer's were allowed into the trial.

The drug is promising as the results of the clinical trial showed a clinical decline of amyloid plaque building up in the group of participants which were administered the antibody. Amyloid plaque is attributed to the cognitive and neuromotor decline of Alzheimer's patients as the disease progresses.

What Is Aducanumab or BIIB037 ?

Aducanumab or BIIB037 is an antibody which is collected from donors who are older with good cognitive skills and no signs of Alzheimer's disease. It is theorized the donors have an immune system which is resistant to Alzheimer's disease. The clinical results of the Phase 1b trial has generated enough promise to speed the trial to a Phase 3 trial.

The Federal Food and Drug Administration (FDA) still has to set the qualifications and approve the guidelines for a Phase 3 trial; but Biogen is expected to recruit participants late in 2015.

Alzheimer's remains one of the most underreported and underfunded diseases which currently affects 5 million Americans. The cost of care for Alzheimer's and dementia related diseases is attributed to one in five Medicare dollars. Researchers have set the goal of finding a treatment by 2025; the cost of the research is estimated at $2 billion a year. The National Institute on Aging continues to rework the allocation of funds dedicated to Alzheimer's research. The 2015 United States federal budget has allocated $638 million to Alzheimer's research and treatment.

ducanumab


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Comments

trufflehunter wrote on March 20, 2015, 11:52 AM

Sounds like good news and hope many are helped not harmed in the process.

wolfgirl569 wrote on March 20, 2015, 2:27 PM

I hope it works well enough to use. It is a very sad disease to see progress

j2jworkz wrote on March 20, 2015, 4:04 PM

It is very brutal indeed. It would be huge if one of these trials could succeed.

Feisty56 wrote on March 20, 2015, 7:24 PM

These are promising results up to this point. Should this approach prove effective and safe, I wonder if the effect will be to stave off advance of Alzeimer's or if it will eradicate the offending plaques altogether.

Gina145 wrote on March 20, 2015, 7:29 PM

Alzheimer's is one of the most frightening things I've ever seen. I've known a few sufferers in my parents' generation, one of whom died last week after a long battle with the disease. I hope this drug proves to be as good as they think it is.

Gina145 wrote on March 20, 2015, 7:31 PM

Even if it eradicates the offending plaques it may be too late to undo what damage has already been done to a sufferer's brain, so my guess is that it would only stop Alzheimer's from advancing.

j2jworkz wrote on March 20, 2015, 8:01 PM

Gina145 Feisty56 I have followed many of the clinical trials through the years, this one does indeed look promising or promising being relative to a clinical trial. Seems like they are due for a breakthrough, let's hope this may be one.

j2jworkz wrote on March 20, 2015, 8:02 PM

Correct, slows the progression if treated in the early stages.

crowntower wrote on March 20, 2015, 9:45 PM

I hope they can find a ways to cure this sickness. Thank you for sharing, why do I have a feeling that if ever --- I will not allow myself to be a test risking body for that kind of medicine. God bless.

allen0187 wrote on March 21, 2015, 1:57 AM

Thank you for sharing this news about the possible treatment for Alzheimer's. Compared to other diseases, it doesn't get the same attention as it should. Considering that the world's population is growing older.

LindaCPearson wrote on March 28, 2015, 9:08 AM

I sure hope they find some drugs and preventative measures for Alzheimer's soon. My mom passed away about 10 years ago after years of suffering from Alzheimer's. It is a vile monster of a disease and heartbreaking for the families of Alzheimer's patients to witness.